2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P11143
    IL4RPep-1 1900734-29-3
    IL4RPep-1 is a peptide that can specifically target atherosclerotic plaque, and its target is IL-4 receptor. IL4RPep-1 exhibits good plaque targeting and is not enriched in normal tissues. IL4RPep-1 has potential application as a targeting delivery system or molecular imaging probe for atherosclerosis research.
    IL4RPep-1
  • HY-P1131A
    M617 TFA 99.38%
    M617 TFA is a selective galanin receptor 1 (GAL1) agonist, with Kis of 0.23 and 5.71 nM for GAL1 and GAL2, respectively. M617 TFA, acting through its central GAL1, can promote GLUT4 expression and enhance GLUT4 content in the cardiac muscle of type 2 diabetic rats.
    M617 TFA
  • HY-P11363
    (Des-Asp1,Ile8)-Angiotensin II 52498-25-6 98.93%
    (Des-Asp1,Ile8)-Angiotensin II is a peptide related to angiotensin II. (Des-Asp1,Ile8)-Angiotensin II can be used for studying the interaction between angiotensin II and its receptors.
    (Des-Asp1,Ile8)-Angiotensin II
  • HY-P11797
    EP9 99.84%
    EP9 is a peptide targeting CD63. EP9 binds specifically to the extracellular region of CD63, including a groove in the large extracellular loop (EC2) or the extracellular end of CD63’s central cavity, triggering endocytosis of decorated nanoemulsions/liposomes into cells. EP9 promotes cellular uptake of decorated nanoemulsions/liposomes into activated cardiac fibroblasts and epicardial stromal cells via caveolae and/or clathrin-coated pits. EP9 can be used for the research of myocardial infarction, cardiac fibrosis.
    EP9
  • HY-P1261A
    Parstatin(mouse) TFA 99.71%
    Parstatin(mouse) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis.
    Parstatin(mouse) TFA
  • HY-P1271A
    Catestatin TFA 99.07%
    Catestatin TFA is a 21-amino acid residue, cationic and hydrophobic peptide. Catestatin TFA is an endogenous peptide that regulates cardiac function and blood pressure. Catestatin TFA is a non-competitive nicotinic antagonist acting through nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release.
    Catestatin TFA
  • HY-P1483B
    Urotensin II, mouse acetate 99.76%
    Urotensin II, mouse acetate is an endogenous ligand for the orphan G-protein-coupled receptor GPR14 or SENR. Urotensin II, mouse acetate is a potent vasoconstrictor. Urotensin II, mouse acetate plays a physiological role in the central nervous system.
    Urotensin II, mouse acetate
  • HY-P1538A
    Fibrinopeptide A, human TFA 61533-47-9 99.51%
    Fibrinopeptide A, human TFA is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH2-termini of the Aα chain.
    Fibrinopeptide A, human TFA
  • HY-P1645B
    Papain (lyophilized powder, ≥10 units/mg protein) 9001-73-4
    Papain (lyophilized powder, ≥10 units/mg protein) is a cysteine protease of the peptidase C1 family. Papain (lyophilized powder, ≥10 units/mg protein) enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain (lyophilized powder, ≥10 units/mg protein) can induce pulmonary emphysema. Papain (lyophilized powder, ≥10 units/mg protein) can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema.
    Papain (lyophilized powder, ≥10 units/mg protein)
  • HY-P1985A
    Notch 1 TFA 98%
    Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types.
    Notch 1 TFA
  • HY-P2728A
    Murine Antithrombin III
    Murine Antithrombin III is a blood coagulation inhibitory enzyme with high catalytic efficiency, high specificity, mild action conditions, etc., and can be used in the pharmaceutical industry, industrial production, food manufacturing, aquaculture and other industries.
    Murine Antithrombin III
  • HY-P3019A
    Urocortin III (human) TFA
    Urocortin III (human) TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) TFA preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) TFA potently binds to type 2 CRF receptors, specifically mCRF2β (Ki = 13.5 nM) and rCRF2α (Ki = 21.7 nM), while demonstrating negligible affinity for hCRF1 (Ki >100 nM). Urocortin III (human) TFA mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion.
    Urocortin III (human) TFA
  • HY-P3557A
    Mibenratide TFA 98%
    Mibenratide TFA, a small cyclic peptide, is an adrenergic β1 receptor antagonist. Mibenratide TFA can be used for heart failure research.
    Mibenratide TFA
  • HY-P3756A
    EPO mimetic peptide-1 acetate
    EPO mimetic peptide-1 (EMP-1) acetate, a 20 amino acid peptide. EPO mimetic peptide-1 acetate stimulates cell proliferation, affects cell cycle and induces the production of reticulocytes in vivo.
    EPO mimetic peptide-1 acetate
  • HY-P3919A
    Adrenotensin (human) TFA 99.09%
    Adrenotensin (human) (Pro-ADM-153-185 (human)) TFA is a 153-185 fragment of precursor peptide of Adrenomedullin. Adrenomedullin (ADM) TFA is a 52-amino acid multifunctional peptide, which belongs to the CGRP superfamily of vasoactive peptide hormones.
    Adrenotensin (human) TFA
  • HY-P4253A
    Arginyl-Glutamine TFA 99.22%
    Arginyl-Glutamine TFA is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy.
    Arginyl-Glutamine TFA
  • HY-P4683A
    (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin acetate 99.81%
    (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin is a potent vasopressin V1 receptor (VP V1R) antagonist. (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin significantly decreases the mean arterial pressure (MAP) in rats.
    (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin acetate
  • HY-P4898A
    Anthopleurin-A TFA 98.39%
    Anthopleurin-A TFA is a soidum channel toxin. Anthopleurin-A TFA is selective for cardiac channels and has cardiotonic effect. Anthopleurin-A TFA can be isolated from the sea anemone.
    Anthopleurin-A TFA
  • HY-P5121B
    γ-Fibrinogen 377-395 scrambled TFA 99.55%
    γ-Fibrinogen 377-395 scrambled TFA is a control peptide that forms a structure similar to that of γ-Fibrinogen 377-395 TFA (HY-P5121A) but possesses a scrambled sequence in the target-binding region.
    γ-Fibrinogen 377-395 scrambled TFA
  • HY-P6023B
    D-Leu-Pro-Arg-Rh110-D-Pro acetate 98%
    D-Leu-Pro-Arg-Rh110-D-Pro acetate is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro acetate consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro acetate can be used to detect FXIa activity.
    D-Leu-Pro-Arg-Rh110-D-Pro acetate
Cat. No. Product Name / Synonyms Application Reactivity